解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract:BACKGROUND:The method described provides a rational means for determining whether to institute chronic anticoagulation to prevent stroke in patients with chronic atrial fibrillation under a variety of clinical circumstances. SUMMARY OF COMMENT:The concept of expected value is used in conjunction with data from clinica...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2128
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Diffusion magnetic resonance imaging (MRI) can quantitatively detect focal ischemic injury within minutes of onset, and perfusion MRI can evaluate the brain's microcirculation. N-Methyl-D-aspartate (NMDA) antagonists and reperfusion can reduce lesion size in stroke models. We used diffusion and p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.2074
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Recent evidence suggests a possible role for leukocytes in ischemic brain injury. This study examined the effect of activation of endogenous circulating leukocytes on cerebral blood flow in normal and neutrophil-depleted rats. METHODS:Leukocytes were activated by rapid injection of either 50 mic...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1977
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:By means of neurological and ophthalmologic examinations we considered whether there is a microcirculatory disorder not related to hypertension and diabetes in patients with lacunar infarcts and whether there are microcirculatory differences in patients with lacunar infarcts compared with those w...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1874
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:To clarify diagnostic entities in ischemic stroke we analyzed the relation between the severity of carotid atherosclerosis, coagulation parameters, lipoproteins, neurological status, and risk factors in 232 patients. METHODS:Duplex ultrasonography, computed tomography scan, and laboratory invest...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.12.1811
更新日期:1993-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Cerebral intraventricular infusion of acidic or basic fibroblast growth factor has been shown to attenuate ischemic damage to hippocampal CA1 neurons in the gerbil. The purpose of the present study was to determine if the basic fibroblast growth factor transgenic mouse has an enhanced ability to ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.11.1735
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Transcranial Doppler ultrasound can detect circulating cerebral emboli. Monitoring of patients with potential embolic sources may allow identification of high-risk patients who can then be selected for prophylactic treatment. However, practical patient monitoring will require automated programs t...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.11.1667
更新日期:1993-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The lipophilic calcium channel antagonist flunarizine has been demonstrated to be neuroprotective in several models of cerebral ischemia. Ischemic spinal cord injury may have a similar pathophysiology and hence may respond in a similar fashion. This study was designed to investigate the effects o...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.10.1547
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:This study was designed to assess the quality of life after an active poststroke period of rehabilitation and to investigate the possibility of a return to a working environment for those still of working age. METHODS:The study was conducted on 180 consecutive patients affected by stroke who wer...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.10.1478
更新日期:1993-10-01 00:00:00
abstract:BACKGROUND:In 15% to 20% of patients with a spontaneous subarachnoid hemorrhage, no aneurysm is found on the first angiogram. This review emphasizes that this group of patients is in fact heterogeneous and describes the clinical features, pattern of hemorrhage on early computed tomographic (CT) scan, prognosis, and pro...
journal_title:Stroke
pub_type: 杂志文章,评审
doi:10.1161/01.str.24.9.1403
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Numerous studies have demonstrated an association between acute cardiac events, cerebrovascular accidents, and cocaine use. The underlying mechanisms leading to these complications have not been well defined. Using various in vitro model systems, it has been reported that cocaine, up to or greate...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.9.1352
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Data from recent multicenter carotid endarterectomy trials have questioned the validity and reliability of Doppler ultrasound in the assessment of carotid stenosis. METHODS:We prospectively analyzed 45 patients undergoing carotid angiography to compare the North American Symptomatic Carotid Enda...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.9.1292
更新日期:1993-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We investigated the effect of hypothermia induced 1 hour after transient (2-hour) middle cerebral artery occlusion on the extent of ischemic cell damage in the rat. METHODS:Middle cerebral artery occlusion was induced extracranially by insertion of a nylon filament into the right internal caroti...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.8.1235
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We studied six patients suffering from pure, unilateral brain stem infarction to explore the association of remote cerebral and cerebellar blood flow changes with damage at different sites of this region of the brain. METHODS:We used single-photon emission computed tomography and [123I]iodoamphe...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.8.1162
更新日期:1993-08-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this study was to determine the 30-day mortality and morbidity of intracerebral hemorrhage in a large metropolitan population and to determine the most important predictors of 30-day outcome. METHODS:We reviewed the medical records and computed tomographic films for all cases of spont...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.7.987
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The administration of glucose has been shown to worsen brain injury in adult animals but has no effect on the severity of injury in newborn rats. We wished to see whether the results in newborn rats could be extended to another newborn animal. METHODS:In 44 0- to 3-day-old piglets, hypoxic-ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.7.1055
更新日期:1993-07-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We earlier reported that risk factors for stroke prepare brain stem tissue for a modified Shwartzman reaction, including the development of ischemia and hemorrhage and the production of tumor necrosis factor-alpha, after a provocative dose of lipopolysaccharide. In the present study, we sought to...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.6.880
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:There have been relatively few community-based studies of long-term prognosis after acute stroke. This study aimed to provide precise estimates of the absolute and relative risks of dying in an unselected cohort of patients with a first-ever stroke. METHODS:Six hundred seventy-five patients were...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.6.796
更新日期:1993-06-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Fibrocartilaginous embolism from the nucleus pulposus has been reported as a rare cause of spinal cord ischemia. We were unable to find previous reports of embolism from this source to cerebral arteries. CASE DESCRIPTION:A previously healthy 17-year-old girl fell during a basketball game. Left h...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.5.738
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Apolipoprotein E polymorphism may influence the early development of coronary artery disease. We investigated the putative role of apolipoprotein E phenotypes in cerebral infarction. METHODS:The apolipoprotein E phenotypes of 69 patients (mean +/- SD age, 72 +/- 11 years) who had suffered comple...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.5.661
更新日期:1993-05-01 00:00:00
abstract:BACKGROUND:Transcranial Doppler monitoring enables the detection of emboli passing through intracranial arteries. Comparison of the different intracranial vessels with respect to emboli detection can be of use in identifying the source of embolism. CASE DESCRIPTION:We report the case of a patient with an acute posteri...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.4.606
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:beta-Blockers prevent vascular events in patients after myocardial infarction and lower blood pressure, the main risk factor for stroke. Hence, we assessed the effects of atenolol on the occurrence of death from vascular causes, stroke, or myocardial infarction and on blood pressure in patients a...
journal_title:Stroke
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1161/01.str.24.4.543
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We found age-related vulnerability to cerebral ischemia in the hippocampus and striatum in spontaneously hypertensive rats. Further study revealed that ischemia-induced release of hippocampal taurine, an inhibitory amino acid, was reduced by 40% in aged rats compared with adult rats, which sugges...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.4.577
更新日期:1993-04-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The aim of this experiment was to study the serial changes in brain intracellular pH, cerebral blood flow, and the oxidation/reduction level of intramitochondrial nicotinamide adenine dinucleotide fluorescence across the cortical surface during severe incomplete global ischemia. METHODS:Reduced ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.3.435
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The etiology of stroke in the young is different from that in older patients and remains unknown in almost one third of the cases. To gain further insight into both pathogenic and etiologic determinants, we prospectively studied a large number of consecutive young adults with focal cerebral ische...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.3.362
更新日期:1993-03-01 00:00:00
abstract:BACKGROUND AND PURPOSE:We have developed a minimally invasive model of photothrombotic occlusion of the distal middle cerebral artery in rats and have evaluated the patterns and features of the resulting histopathologic injury in two normotensive strains. METHODS:Food-deprived male Sprague-Dawley (n = 14) and Wistar (...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.2.286
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The present study was performed to determine the relation between distribution of atherosclerosis and risk factors in Japanese patients with atherothrombotic occlusion. METHODS:We studied 154 patients with atherothrombotic occlusion of the extracranial internal carotid artery (n = 75, ICA group)...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.2.206
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Using the dexamethasone suppression test, we studied the suppressibility of the cortisol axis and its clinical determinants at various time points after stroke. A major aim was to examine the dexamethasone test as a diagnostic tool for the diagnosis of major depression in stroke patients. METHOD...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.24.1.52
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Nimodipine, a calcium antagonist, has been reported to have beneficial effects in acute ischemic infarction. Some calcium channel antagonists have antiplatelet effects. We investigated the effect of oral nimodipine on platelet function in healthy volunteers. METHODS:Twelve healthy volunteers (6 ...
journal_title:Stroke
pub_type: 临床试验,杂志文章
doi:10.1161/01.str.24.1.10
更新日期:1993-01-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Studies of the cerebroprotective effects of selective brain cooling have failed to show amelioration of ischemic injury in the cerebral cortex. This study was designed to test the hypothesis that mild-to-moderate selective brain cooling initiated after the onset of global brain ischemia in rats p...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.12.1792
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND:We studied 60 patients longitudinally to examine relations between regional cerebral blood flow and depressive states after stroke. METHODS:Poststroke depressive states were assessed by the Zung Self-Rating Depression Scale (SDS). Regional cerebral blood flow was measured using the 133xenon inhalation metho...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.12.1716
更新日期:1992-12-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Although our previous study demonstrated that dementia of the Binswanger type may be a disconnection dementia caused by leukoaraiosis, some hypertensive patients with marked leukoaraiosis do not develop dementia. The goal of the present study is to elucidate the pathophysiology of nondemented hyp...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1673
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Exogenously administered fructose-1,6-bisphosphate reduces neuronal injury from hypoxic or ischemic brain insults. To test the hypothesis that fructose-1,6-bisphosphate prevents changes in intracellular calcium ([Ca2+]i) and high-energy phosphate levels, we measured [Ca2+]i, intracellular pH (pHi...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.11.1617
更新日期:1992-11-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Victims of air embolism often recover rapidly on hyperbaric treatment then deteriorate again, even if hyperbaric treatment is continued. In previous animal experiments, lidocaine has been shown to improve recovery of somatosensory evoked response amplitude after air embolism. However, animals in ...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.10.1515
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Close relations between leukoaraiosis detected by computed tomography or magnetic resonance imaging and stroke, particularly lacunar infarction, have been reported. We studied whether leukoaraiosis is related to long-term prognosis for patients with lacunar infarction. METHODS:We examined monthl...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.10.1434
更新日期:1992-10-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Reduction of cerebral blood flow results in several acute metabolic disturbances, including a reduction in Na,K-ATPase activity. The relation between this reduction and the onset of edema is unknown, as is the effect of restoration of blood flow. Therefore, we investigated the role of decreased N...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1331
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:The presence of known restriction fragment length polymorphisms in the apoprotein A-I-C-III gene cluster, which encodes their respective apoproteins, was investigated using the restriction enzymes Sac I and Pst I to determine the potential role of genetic variations for stroke risk in an American...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1257
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:In a previous study, we occasionally found that the rat given naloxone in the preoptic region develops behavioral seizures. In view of knowledge that the forebrain including the medial septal nucleus provides cholinergic projections to the hippocampal formation, the present study examined the eff...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1325
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Elevated low density lipoprotein and reduced high density lipoprotein cholesterol may increase the risk of atherothrombotic brain infarction, but the metabolic mechanisms accounting for this relation are poorly understood. METHODS:The kinetic parameters of low density and high density lipoprotei...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.9.1265
更新日期:1992-09-01 00:00:00
abstract:BACKGROUND AND PURPOSE:Dichloroacetate facilitates a decrease in brain lactate during reperfusion after incomplete ischemia. This study examined the possible activation of pyruvate dehydrogenase enzyme by dichloroacetate to explain this effect. Because the duration of ischemia and hyperglycemia exacerbate ischemic brai...
journal_title:Stroke
pub_type: 杂志文章
doi:10.1161/01.str.23.8.1145
更新日期:1992-08-01 00:00:00